|
KMID : 0380620110430050624
|
|
Korean Journal of Food Science and Technology
2011 Volume.43 No. 5 p.624 ~ p.632
|
|
|
Antioxidant and Anti-inflammatory Activities of Extracts from Korean Traditional Medicinal Prescriptions
|
|
Lee Sung-Kyu
Lee Eun-Ju
Park Woo-Dong
Kim Jong-Boo
Choi Sang-Won
|
|
|
Abstract
|
|
|
|
Water and ethanol extracts of 16 different Korean traditional oriental prescriptions used widely for prevention of degenerative arthritis were prepared and their total phenolic and total flavonoid contents were quantified. Additionally, antioxidant and anti-inflammatory activities of water, ethanol and enzyme-treated extracts were determined by in vitro assays. Total phenolic and total flavonoid contents of three extracts from the 16 different medicinal prescriptions varied from 10.03-78.03 and 0-16.24 mg/g, respectively. Among the three extracts of 16 different medicinal prescriptions tested, ‘Mahangeuigamtang’ showed the potent full term for DPPH (RC50=71.26, 27.33, 63.00 μg/mL) and full term for ABTS (RC50=21.11, 27.45, 152.11 μg/mL) radical scavenging activities, and its water and ethanol extracts exhibited significant cyclooxygenase-2 (COX-2) inhibitory activity (49.10 and 69.06%, respectively). Ethanol and enzyme-treated extracts of ‘Euieuiintang ’ exerted the strongest COX-2 inhibitory activity (68.23 and 75.05%, respectively). ‘Mahangeuigamtang’ and ‘Euieuiintang’ may be useful as potential therapeutic agents for treatment of degenerative diseases, such as inflammation and aging.
|
|
|
KEYWORD
|
|
|
traditional medicinal prescriptions, total phenolic content, total flavonoid content, free radicals, COX-2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|